منابع مشابه
Once and only once.
V enous thrombosis is a fairly common disorder that manifests mainly as deep vein thrombosis of the leg or pulmonary embolism. It affects 1 in 1000 individuals annually and has a substantial mortality rate. 1 Its causes are both genetic (prothrombotic abnormalities sometimes referred to as a group as thrombophilia) and acquired. 2 Among the latter are cancer, female hormone use, and all forms o...
متن کاملBaseline findings of the Italian multicenter randomized controlled trial of "once-only sigmoidoscopy"--SCORE.
BACKGROUND A single sigmoidoscopy examination at around age 60 years has been proposed as a cost-effective strategy to prevent colorectal cancer. A multicenter randomized controlled trial, the SCORE trial, is in progress in Italy to estimate the impact of this strategy on colorectal cancer incidence and mortality and the duration of the protective effect. We present the baseline screening outco...
متن کاملOnce-only flexible sigmoidoscopy screening in prevention of colorectal cancer: a multicentre randomised controlled trial
BACKGROUND Colorectal cancer is the third most common cancer worldwide and has a high mortality rate. We tested the hypothesis that only one flexible sigmoidoscopy screening between 55 and 64 years of age can substantially reduce colorectal cancer incidence and mortality. METHODS This randomised controlled trial was undertaken in 14 UK centres. 170 432 eligible men and women, who had indicate...
متن کاملFlexible sigmoidoscopy screening: is once enough?
www.thelancet.com Published online February 21, 2017 http://dx.doi.org/10.1016/S0140-6736(17)30542-1 1 Worldwide, colorectal cancer is the third most common incident cancer and the fourth leading cause of cancer death, with 1·4 million new cases and 700 000 deaths estimated in 2012—most of these from the developed world. Over the past three decades, several methods to screen for colorectal canc...
متن کاملDNA Replication: Once, and only once
The preparation for DNA replication initiation is tightly linked to cell-cycle progression, ensuring that replication occurs only once per cycle. The time is ripe for a molecular dissection of the links between the two processes.
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1999
ISSN: 0923-7534
DOI: 10.1093/annonc/10.suppl_6.s65